Bioengineered Tooth Buds Exhibit Features of Natural Tooth Buds

Infected Mandibular Fracture; Can the Tooth Buds Be Saved?

Mandibular fracture in children usually results in the involvement of a tooth bud directly in the fracture line. A study by Koenig et al (1994) proves that the injury has the potential to damage the developing tooth germ. The presence of infection may also adversely affect the developing tooth and the fracture union. Specific treatment guidelines for developing tooth buds located in the line of...

Whole Tooth Regeneration Using a Bioengineered Tooth

Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model

Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Recently, many basic studies of whole-tooth replacement using three-dimensional cell manipulation have been conducted in a mouse model. Further evidence of the practical application to hu...

Frozen buds

close-up, the flower buds of the weed Arabidopsis thaliana appear almost animal-like. The scanning electron micrographs above show a whole inflorescence (top right) and two individual flower buds in detail. The bud of a Columbia wild-type plant shown at bottom right has an oval shape and is tightly closed — as buds normally remain until the anther matures inside. By contrast, the bud on the lef...

Functional Tooth Regeneration Using a Bioengineered Tooth Unit as a Mature Organ Replacement Regenerative Therapy

Donor organ transplantation is currently an essential therapeutic approach to the replacement of a dysfunctional organ as a result of disease, injury or aging in vivo. Recent progress in the area of regenerative therapy has the potential to lead to bioengineered mature organ replacement in the future. In this proof of concept study, we here report a further development in this regard in which a...